

Monthly 5-in-1 Spot-On for Heartworm, Fleas and Parasites in Cats
Product Description
Barrier Topical Solution (Purple Box) is an FDA-approved, prescription-only monthly spot-on for cats and kittens 9 weeks or older, weighing 9.1 to 18 lbs. Each 0.8 mL tube contains 10% imidacloprid and 1% moxidectin, the same active ingredients as Advantage Multi for Cats. One monthly dose prevents heartworm, kills adult fleas, treats ear mites, and controls roundworm and hookworm infections in cats.
Benefits
- Prevents Heartworm Disease: Moxidectin prevents Dirofilaria immitis larval development into adult heartworms when applied once monthly to cats.
- Kills Adult Fleas: Imidacloprid kills adult fleas beginning within 12 hours of application, providing fast and effective flea relief.
- Treats Ear Mite Infestations: Treats and controls Otodectes cynotis ear mite infestations in cats with a single monthly topical application.
- Treats Roundworms: Treats and controls Toxocara cati intestinal roundworm infections in cats effectively with each monthly dose.
- Treats Hookworms: Treats and controls Ancylostoma tubaeforme intestinal hookworm infections in cats effectively with every monthly application.
- Same Ingredients, Better Value: Contains the same active ingredients as Advantage Multi for Cats, offering equivalent five-in-one parasite protection.
- Easy Twist-to-Open Applicator: Features a twist-to-open cap that breaks the seal without removal, making monthly application simple and mess-free.
- Made in the USA: Manufactured and packaged in the USA from a registered FDA facility, ensuring quality and regulatory compliance.
Ingredients
Composition Table
| Ingredient | Quantity |
| Imidacloprid | 10% (80 mg per 0.8 mL tube) |
| Moxidectin | 1% (8 mg per 0.8 mL tube) |
Other Ingredients
Benzyl alcohol, Propylene carbonate
How to Use
Directions for Use
- Prescription Required: US law allows this medication only when a licensed vet prescribes or authorizes it.
- Open the Tube Correctly: Hold the tube straight, break the seal by twisting the cap, and keep it attached while applying.
- Apply at Neck Base: Separate the fur at the base of the cat's head until the skin is clearly visible before applying.
- Squeeze Entire Contents: Squeeze all the contents onto a single exposed spot on the skin, avoid rubbing, and allow it to air dry.
- Lift Tube Before Releasing: Remove the tube from the skin before releasing pressure to avoid drawing the solution back into the tube.
- Apply Once Monthly: Give this treatment every 30 days to keep continuous protection against heartworms, fleas, and parasites.
- Prevent Post-Application Licking: Keep the cat from licking the application site for 30 minutes and separate pets until the area dries.
- Test for Heartworm First: Test all cats for existing heartworm disease before beginning a heartworm prevention protocol with Barrier for Cats.
Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.
Additional Information
Precautions
- Minimum Age and Weight: Do not use in cats under 9 weeks of age or weighing less than 2 lbs.
- Sick or Underweight Cats: Never apply Barrier to sick, debilitated, or underweight cats regardless of their age or current body weight.
- Breeding, Pregnant, Lactating Cats: Safety has not been established in breeding, pregnant, or lactating cats; always consult your veterinarian before use.
- Geriatric Cats: Use with caution in older cats that may have undiagnosed underlying health conditions and consult your veterinarian first.
- Licking Prevention Critical: Accidental ingestion or licking of the product may cause hypersalivation, tremors, vomiting, and decreased appetite in cats.
- Bathing Efficacy Not Evaluated: Effectiveness against heartworm after bathing has not been evaluated; avoid bathing the cat close to application time.
- Keep Children Away: Children should not come into contact with the application site for at least 30 minutes after applying.
- Eye Irritant for Humans: Avoid eye contact, wash hands thoroughly after handling, and flush eyes with water immediately if accidental contact occurs.
Possible Side Effects
- Hypersalivation: Excessive drooling can occur if the cat grooms the treated area; applying at the head base reduces licking access.
- Vomiting and Decreased Appetite: Vomiting and reduced appetite have been reported when the product is accidentally ingested through self-grooming by cats.
- Tremors: Neurological tremors have been reported following accidental ingestion of the product; contact your veterinarian immediately if this occurs.
- Application Site Reactions: Stiff, oily hair at the application site may appear temporarily; this is cosmetic and does not affect product safety.
- Human Adverse Reactions: Human exposure may cause headache, dizziness, and skin redness, burning, or tingling; seek medical attention if these symptoms occur.
Storage Information
- Store at Cool Temperature: Store between 4°C (39°F) and 25°C (77°F); avoid exposure to excess heat or cold at all times.
- Secure Storage Required: Store this prescription product securely out of reach of children and other animals at all times.
Shipping & Return
We offer ground, express, and priority delivery; see our shipping policy for details.
For return instructions or product concerns, please refer to our detailed refund policy.
Prescription items are NON-RETURNABLE and NON-REFUNDABLE.
Frequently Asked Questions
Q1: What does Barrier Topical Solution (Purple Box) treat and prevent in cats?
Ans: This is a monthly spot-on treatment for cats that prevents heartworms, eliminates adult fleas, treats flea problems, controls ear mites, and handles roundworm and hookworm infections in kittens and adult cats over 9 weeks old.
Q2: How does Barrier for Cats compare to Advantage Multi for Cats?
Ans: Barrier for Cats contains the same active ingredients as Advantage Multi, 10% imidacloprid and 1% moxidectin, at identical concentrations. Both are FDA-approved monthly prescription topicals offering equivalent five-in-one parasite protection, with the primary difference being the brand name and price.
Q3: How do the two active ingredients in Barrier for Cats work?
Ans: Imidacloprid targets the nervous system of fleas, causing paralysis and rapid death within 12 hours of application. Moxidectin is absorbed into the bloodstream after topical application, where it disrupts the nervous systems of heartworm larvae, roundworms, and hookworms, preventing development and eliminating existing infections.
Q4: Can Barrier be used in cats weighing more than 18 lbs?
Ans: For cats over 18 lbs, an appropriate combination of Barrier tube sizes should be used to reach the correct dose, as directed by your veterinarian. Never use a single Purple Box tube alone for cats exceeding 18 lbs without veterinary guidance.
Q5: Is the monthly cat spot-on safe for pregnant or lactating cats?
Ans: Barrier for Cats has not been tested for safety in breeding, pregnant, or nursing cats. If your cat is in any of these stages, talk to your vet before starting parasite prevention.
Clinical Research
Imidacloprid – Flea Control Mechanism (NPIC)
Moxidectin – Antiparasitic Applications in Skin Disease (MSD Veterinary Manual)
Feline Heartworm Disease Overview (American Heartworm Society)
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