
Monthly topical protection against key feline parasites
Product Description
NexGard COMBO is a prescription topical solution for cats weighing 5.6–16.5 lbs. It provides broad-spectrum parasite protection by killing adult fleas and controlling certain ticks for one month, preventing heartworm disease, and treating and controlling common intestinal worms. The dose is applied to the skin on the neck using a single-use applicator once monthly, as directed.
Benefits
- Broad Coverage: Kills fleas, controls ticks, prevents heartworm, treats intestinal worms.
- Once-Monthly Dosing: Applies monthly for consistent parasite protection coverage.
- Topical Convenience: No tablets needed; simple spot-on administration.
- Weight-Specific Dose: Designed for cats in the 5.6–16.5 lb range.
- Multi-Ingredient Action: Combines three actives for internal and external control.

Variants
- NexGard COMBO Topical for Cats 1.8-5.5 lbs
- NexGard COMBO Topical for Cats 5.6-16.5 lbs
Ingredients
Active Ingredients
Esafoxolaner, Eprinomectin, Praziquantel
How to Use
Directions for Use
- Dosing Chart:6–16.5 lb. cats use 0.9 mL applicator; apply entire contents.
- Monthly Schedule: Apply topically once a month, as directed.
- Application Site: Apply on the neck between the skull base and the shoulder blades.
- Skin Placement: Part hair to skin and apply in one spot only.
- Hand Hygiene: Wash hands with soap and water after use.
Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.
Additional Information
Precautions
- Topical Only: Do not administer orally; ingestion may cause excessive salivation.
- Human Contact: Avoid contact with the application site for 4 hours or until dry.
- Neurologic Caution: Use cautiously in cats with seizures or neurologic disorders.
- Age/weight Limits: Not tested in kittens under 8 weeks or under 1.8 lbs.
- Breeding Status: Safety not fully evaluated in breeding, pregnancy, or lactating cats.
Shipping & Returns
We offer ground, express, priority, and international delivery; see our shipping policy for details.
For return instructions or product concerns, please refer to our detailed refund policy.
Prescription items are NON-RETURNABLE and NON-REFUNDABLE.
Frequently Asked Questions
Q1: What parasites does NexGard COMBO protect cats against?
Ans: NexGard COMBO is indicated to prevent heartworm disease and to treat and control roundworms, hookworms, and tapeworms. NexGard COMBO also kills adult fleas and is indicated for the treatment and prevention of flea infestations, as well as specific tick infestations, for a period of one month.
Q2: How often is NexGard COMBO applied for ongoing protection?
Ans: NexGard COMBO is applied topically once a month. Monthly dosing provides continuous protection against labeled parasites. It can be used year-round, based on regional parasite risk and veterinary guidance, particularly for heartworm prevention, where consistent monthly dosing is crucial.
Q3: Where exactly should the topical dose be applied to a cat?
Ans: Apply the full contents to the skin on the midline of the neck, between the base of the skull and the shoulder blades. Part the hair until skin is visible, then apply it in one spot on an area the cat cannot lick.
Q4: What is the correct dose for cats weighing 5.6–16.5 lbs?
Ans: For cats weighing 5.6–16.5 lbs, use the 0.9 mL unit applicator and apply the entire contents topically in a single spot. Using the correct weight-range applicator helps ensure the intended minimum dosing of all active ingredients.
Q5: Can cats lick the application area after NexGard COMBO is applied?
Ans: Cats should not be able to lick the application site. Apply to the neck area where licking is minimized and prevent contact between pets until the site is dry. If licking occurs, oral exposure can lead to excessive salivation.
Q6: Are there warnings about neurologic side effects with NexGard COMBO?
Ans: Esafoxolaner is an isoxazoline, a class associated with neurologic adverse reactions such as tremors, ataxia, and seizures. Seizures have been reported even without prior history, so use caution in cats with seizure or neurologic disorders.
Q7: Is NexGard COMBO approved for kittens?
Ans: NexGard COMBO is indicated for cats and kittens 8 weeks of age and older and weighing 1.8 lbs or greater. The product has not been tested in kittens younger than 8 weeks or weighing less than 1.8 lbs.
Q8: What should people do after applying the topical solution?
Ans: Avoid direct contact with the application site for 4 hours or until the area is visibly dry. Wash your hands with soap and water after application. The product may cause mild to moderate eye irritation, so avoid eye contact.
Q9: Does NexGard COMBO require a prescription?
Ans: Yes. NexGard COMBO is a prescription animal drug and should be used by or on the order of a licensed veterinarian. Veterinary direction helps ensure the correct weight-range product selection and appropriate parasite prevention strategy for the cat.
Q10: What should happen if a monthly dose is missed?
Ans: If a dose is missed and the 30-day interval between doses is exceeded, apply NexGard COMBO immediately and resume the monthly dosing schedule. Consistent monthly dosing is especially important when using NexGard COMBO for heartworm prevention.
Thank you for shopping with us. This Shipping Policy outlines how and when orders are processed, shipped, and delivered after being placed on our website. By placing an order, you agree to the terms described below.
1. Order Processing Time
Order Cut-Off Time: Orders placed on business days before 6:00 PM local business time are considered received on the same day.
Orders placed after 6:00 PM, on weekends, or on public holidays will be processed on the next business day.
Processing Time: Orders are typically processed and prepared for shipment within 1–5 business days after the order is received.
Processing time includes order verification, quality checks, and packaging.
Processing time does not include shipping or delivery time.
2. Shipping Methods and Delivery Time
We currently offer the following shipping methods at checkout:
Priority Shipping: $5.99
Expected delivery time: 1–2 business days
Standard Shipping: $2.99
Expected delivery time: 3–6 business days
Free Shipping: $0
Expected delivery time: 5–8 business days
Delivery times are estimated from the time the order has been shipped and may vary depending on the shipping destination, carrier operations, weather conditions, holidays, or other unforeseen delays.
Estimated delivery times are provided for reference only and are not guaranteed.
3. Shipping Carriers
We work with reliable third-party shipping carriers to deliver your orders safely and efficiently. Carrier selection is determined based on destination, package size, and service availability.
Carrier delays are outside of our control, and we are not responsible for delays caused by the carrier.
4. Shipping Costs
We ship orders to addresses within the United States.
Shipping costs are displayed at checkout based on the shipping method selected by the customer.
Available shipping options may include Priority Shipping, Standard Shipping, and Free Shipping.
No additional standard shipping fees will be charged beyond the shipping cost shown at checkout.
5. Order Tracking
Once your order has shipped, you will receive a shipping confirmation email containing tracking information if available.
Please allow up to 48 hours for tracking details to become active.
6. Incorrect or Incomplete Address
Please ensure that your shipping address is accurate and complete at checkout.
We are not responsible for delays caused by incorrect or incomplete address information, or for packages that are lost or undeliverable due to address errors.
Additional shipping or handling fees may apply for re-delivery.
7. Lost or Delayed Shipments
If your order has not arrived within the estimated delivery timeframe, please contact our customer support team.
We will assist in investigating the issue with the carrier.
While we strive to help resolve shipping issues, we are not responsible for delays or losses caused by third-party carriers.
8. Damaged Packages
If your package arrives damaged, please contact us within a reasonable time after delivery and provide clear photos of the damaged packaging and items.
We will review the case and assist according to our Return & Refund Policy.
9. Policy Updates
We reserve the right to modify or update this Shipping Policy at any time.
Changes will be effective immediately upon posting on this page.
10. Contact Us
If you have any questions regarding this Shipping Policy or your order status, please contact us using the contact information provided in the footer.
Thank you for shopping with us. This Return & Refund Policy explains the terms and conditions under which returns and refunds are accepted for purchases made through our website. By placing an order, you agree to the terms outlined below.
1. No Exchange Policy
We do not offer exchanges at this time.
This policy allows us to maintain efficient inventory management, faster order processing, and consistent product availability for all customers. If you would like a different item, size, color, or version, please return the original item (if eligible) and place a new order separately.
2. Return Eligibility
You may request a return if all of the following conditions are met:
The return request is submitted within 30 days of confirmed delivery
The item is unused, unwashed, and in its original condition
The item includes all original packaging, tags, accessories, and documentation
The item is not listed as non-returnable (see Section 3)
Returns requested after the 30-day period will not be accepted.
3. Non-Returnable Items
The following items are not eligible for return:
Items marked as Final Sale or Non-Returnable at the time of purchase
Gift cards or store credit
Digital products or downloadable content
Items that show signs of use, damage, or alteration not caused by us
4. How to Initiate a Return
To start a return, please contact our customer support team and provide:
Your order number
The item(s) you wish to return
Reason for return (for internal reference only)
Returns sent without prior authorization may be refused.
5. Return Shipping
Customers are responsible for return shipping costs unless the return is due to a defective or incorrect item.
We recommend using a trackable shipping method, as we are not responsible for lost or damaged return shipments.
Original shipping fees are non-refundable, except where required by law.
6. Refunds
Once we receive and inspect your returned item, we will notify you of the approval or rejection of your refund.
If approved:
Refunds will be issued to the original payment method
Processing typically takes 1–3 business days, depending on your payment provider
Refund amounts may be reduced for items returned in unacceptable condition
7. Damaged or Incorrect Items
If you receive an item that is damaged, defective, or incorrect, please contact us within a reasonable time after delivery and provide clear photos of the issue. We will review the case and, if approved, issue a refund in accordance with this policy.
8. Refused or Undeliverable Shipments
Orders that are refused or returned due to incorrect shipping information may be subject to additional handling or shipping fees, which may be deducted from the refund amount.
9. Policy Updates
We reserve the right to update or modify this Return & Refund Policy at any time. Changes will be effective immediately upon posting on this page.
10. Contact Us
If you have any questions regarding this Return & Refund Policy or need assistance with a return, please contact us using the contact information provided in the footer.
Customer reviews
See what customers are saying about this product.
